OVERVIEW OF ACTIVITY

Colorectal cancer is among the most common types of cancer in the United States, and management strategies are continuously evolving. Published results from ongoing clinical trials lead to the emergence of new therapeutic agents and regimens and changes in the indications, doses and schedules for existing treatments. In order to offer optimal patient care — including the option of clinical trial participation — the practicing medical oncologist must be well informed of these advances. To bridge the gap between research and patient care, Colorectal Cancer Update utilizes one-on-one discussions with leading oncology investigators. By providing access to the latest research developments and expert perspectives, this CME activity assists medical oncologists with the formulation of up-to-date clinical management strategies.

LEARNING OBJECTIVES

• Describe the ongoing trials that are evaluating the addition of biologic agents to conventional chemotherapy for the adjuvant treatment of Stage II and Stage III colon cancer.
• Utilize biomarkers to identify appropriate patients with colorectal cancer (CRC) who may respond to treatment with EGFR inhibitors.
• Compare and contrast the benefits and risks of evidence-based chemobiologic treatment regimens for the front-line management of metastatic CRC.
• Select patients for surgical resection of isolated hepatic and extrahepatic CRC metastases based on assessment of disease burden, anatomic location and residual organ function.
• Appraise the clinical impact of perioperative systemic therapy on local recurrence rates and long-term outcomes for patients with resectable hepatic CRC metastases.
• Describe the preclinical and clinical research on the antitumor mechanisms of angiogenesis inhibitors.

ACCREDITATION STATEMENT

Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

Research To Practice designates this educational activity for a maximum of 3 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

HOW TO USE THIS CME ACTIVITY

This CME activity contains both audio and print components. To receive credit, the participant should review the CME information, listen to the CDs and complete the Post-test and Educational Assessment and Credit Form located in our website at ResearchToPractice.com/CCU. ResearchToPractice.com/CCU includes an easy-to-use, interactive version of this monograph with links to relevant full-text articles, abstracts, trial information and other web resources indicated here in blue underlined text.

This program is supported by educational grants from Genentech BioOncology and Sanofi-Aventis.