Colorectal Cancer Update
                A Continuing Medical Education Audio Series
              STATEMENT OF NEED / TARGET AUDIENCE
              Colorectal cancer is among the most common cancers in the United States, and the arena of colorectal cancer  
                treatment continues to evolve. Published results from ongoing clinical trials lead to the emergence of new therapeutic  
                agents and regimens and changes in indications, doses and schedules for existing treatments. In order to  
                offer optimal patient care — including the option of clinical trial participation — the practicing medical oncologist  
                must be well informed of these advances.
              To bridge the gap between research and patient care, Colorectal Cancer Update utilizes one-on-one  
                discussions with leading oncology investigators. By providing access to the latest research developments and  
                expert perspectives, this CME activity assists medical oncologists in the formulation of up-to-date clinical  
                management strategies.
              GLOBAL LEARNING OBJECTIVES
              
                - Critically evaluate the clinical implications of emerging clinical trial data in colorectal cancer treatment, and  
                  incorporate these data into management strategies in the local and advanced disease settings.
 
                - Counsel appropriate patients about the availability of ongoing clinical trials.
 
                - Evaluate the emerging research data on various adjuvant chemotherapy approaches, including the use of  
                  oxaliplatin-containing regimens and the use of capecitabine or intravenous 5-FU, and explain the absolute  
                  risks and benefits of these regimens to patients.
 
                - Evaluate emerging research data on various neoadjuvant radiation therapy/chemotherapy approaches to  
                  rectal cancer and explain the absolute risks and benefits of these regimens to patients.
 
                - Integrate emerging data on biologic therapies into management strategies for patients with advanced  
                  colorectal cancer.
 
              
              PURPOSE OF THIS ISSUE OF COLORECTAL CANCER UPDATE
              The purpose of Issue 2 of Colorectal Cancer Update is to support these global objectives by offering the perspectives  
                of Drs Marshall, Saltz, Cassidy, Ravdin and Wolmark on the integration of emerging clinical research data into  
                the management of colorectal cancer.
              ACCREDITATION STATEMENT
              Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide  
                continuing medical education for physicians.
              CREDIT DESIGNATION STATEMENT
              Research To Practice designates this educational activity for a maximum of 2.75 AMA PRA Category 1 Credit(s)™.  
                Physicians should only claim credit commensurate with the extent of their participation in the activity.
              HOW TO USE THIS CME ACTIVITY
              This CME activity contains both audio and print components. To receive credit, the participant should listen to the  
                CDs, review the monograph and complete the Post-test and Evaluation Form located in the back of this monograph  
                or on our website. This monograph contains edited comments, clinical trial schemas, graphics and references  
                that supplement the audio program. ColorectalCancerUpdate.com includes an easy-to-use, interactive version  
                of this monograph with links to relevant full-text articles, abstracts, trial information and other web resources  
                indicated here in blue underlined text.
              This program is supported by education grants from Genentech BioOncology, Roche Laboratories Inc and  
                Sanofi-Aventis.