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Go to interview with Norman Wolmark, MD
Go to interview with John L Marshall, MD
Go to interview with Howard S Hochster, MD
Go to interview with Michael J O’Connell, MD
Go to interview with Herbert Hurwitz, MD
Highlights of the NSABP CME Symposium

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Norman Wolmark, MD
Professor and Chairman
Department of Human Oncology
Allegheny General Hospital
Professor, Drexel University College of Medicine
Chairman, NSABP
Pittsburgh, Pennsylvania
 
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Track 1 Introduction
Track 2 Adjuvant chemotherapy for Stage II colon cancer
Track 3 Development and validation of a prognostic assay in colon cancer
Track 4 Perspectives on ECOG-E5202 adjuvant trial design
Track 5 NSABP-C-08: FOLFOX with or without bevacizumab in the adjuvant setting
Track 6 Future adjuvant NSABP colon trial design
Track 7 Emerging clinical research on panitumumab
Track 8 NSABP-C-09: CAPOX with or without hepatic arterial infusion of FUDR following hepatic resection
Track 9 NSABP-C-10: FOLFOX plus bevacizumab for patients with a synchronous primary lesion and metastatic disease
Track 10 Perspectives on NSABP-R-04 trial design
Track 11 Adjuvant chemotherapy for rectal cancer
     
John L Marshall, MD
Chief, Hematology and Oncology
Director of Developmental Therapeutics and GI Oncology
Lombardi Comprehensive Cancer Center
Georgetown University
Washington, DC
 
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Track 1 Introduction
Track 2 EGFR inhibitors in the management of colon cancer
Track 3 Clinical trial experience with cetuximab
Track 4 Synergy between cetuximab and chemotherapy
Track 5 Similarities and differences between panitumumab and cetuximab
Track 6 Incorporating EGFR inhibitors into the treatment algorithm
Track 7 Management of rash associated with EGFR inhibitors
Track 8 Potential role of panitumumab in clinical practice
Track 9 Adjuvant chemotherapy for Stage II colon cancer
Track 10 Adjuvant capecitabine for patients with Stage II disease
Track 11 Case discussion: An 84-year-old man with Stage II colon cancer
     
Howard S Hochster, MD
Professor of Medicine and Clinical Pharmacology
New York University Cancer Institute
New York, New York
 
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Track 1 Introduction
Track 2 Background, design and results of TREE-1 and TREE-2 trials
Track 3 Efficacy of bFOL regimen in TREE-1 and TREE-2
Track 4 Selection of first-line therapy for metastatic disease
Track 5 Management of patients with neurotoxicity who progress on FOLFOX with bevacizumab
Track 6 Management of oxaliplatin-associated neurotoxicity
Track 7 Selection of first-line therapy for patients who have received adjuvant FOLFOX
Track 8 Potential benefits of panitumumab versus cetuximab
Track 9 Future directions in the management of colon cancer
     
Michael J O’Connell, MD
Professor of Human Oncology
Drexel University College of Medicine
Director, Allegheny Cancer Center
Director, Division of Medical Oncology
Allegheny General Hospital
Associate Chairman, NSABP
Pittsburgh, Pennsylvania
 
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Track 1 Introduction
Track 2 Identification of prognostic genes in colon cancer
Track 3 Ongoing development of a prognostic assay for colon cancer
Track 4 Significance of 18Q deletion and DCC expression
Track 5 Future directions in colon cancer based on prognostic assays
Track 6 Adjuvant chemotherapy for Stage II colon cancer
Track 7 Rationale for incorporation of patients with Stage II disease into NSABP-C-08
Track 8 Side effects associated with bevacizumab observed in NSABP-C-08
Track 9 Efficacy and tolerability of panitumumab
Track 10 Future directions for NSABP adjuvant colon cancer trials
Track 11 NSABP-R-04: Neoadjuvant radiation therapy and capecitabine with or without oxaliplatin versus neoadjuvant radiation therapy and infusional 5-FU in rectal cancer
Track 12 Ongoing and future trials in the NSABP
     
Herbert Hurwitz, MD
Associate Professor of Medicine
Division of Hematology/Oncology
Clinical Director, Phase I Program
Co-leader, GI Oncology Program
Duke University Medical Center
Durham, North Carolina
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Track 1 Introduction
Track 2 Side-effect profile of bevacizumab
Track 3 Bowel perforation associated with bevacizumab
Track 4 Bevacizumab-related hypertension
Track 5 Predictive risk factors for arterial thromboembolic events with bevacizumab
Track 6 Potential rationale for lack of benefit with adjuvant irinotecan
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Track 7 Impact of exercise and diet on cancer relapse
Track 8 Selection of adjuvant chemotherapy
Track 9 Role of capecitabine in the adjuvant setting
Track 10 Substitution of capecitabine for 5-FU as neoadjuvant therapy for rectal cancer
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Track 11 First-line therapy for metastatic disease
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Track 12 Sequencing panitumumab in the clinical algorithm
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Track 13 Potential benefits and challenges of combined biologic therapy
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Highlights of the NSABP CME Symposium

 
  Click here to download the entire segment  
Track 1 Introduction
Track 2 Differences between management of breast and colon cancer
Track 3 Historical perspective on the role of adjuvant chemotherapy for Stage II colon cancer
Track 4 Ongoing development of prognostic assays to predict benefit of adjuvant chemotherapy in colon cancer
Track 5 Patient perspectives on adjuvant chemotherapy for Stage II disease
Track 6 Differences in medical oncologists’ approach to colon cancer
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Track 7 Safety and efficacy of bevacizumab
Track 8 Hypertension as a predictor of response to bevacizumab
Track 9 Utility of EGFR staining in clinical decision-making
Track 10 Efficacy and tolerability of cetuximab
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Track 11 Phase III trial of best supportive care with or without panitumumab
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Track 12 Impact of rash on use of EGFR inhibitors
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Track 13 Potential role of combined biologic therapy
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Track 14 Future directions for NSABP adjuvant colon cancer trials
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Track 15 Selection of panitumumab versus cetuximab in clinical practice
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Track 16 TREE-1 and TREE-2 trials evaluating oxaliplatin/fluoropyrimidine regimens with and without bevacizumab as first-line therapy
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